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Takeda announces SGN-35 ADC trial results in Hodgkin lymphoma patients

July 27, 2017

To determine how physical limitations following initial breast cancer treatment affect mortality, the scientists studied 2,202 women in California and Utah with breast cancer, questioning them about endurance, strength, muscular range of motion, and small muscle dexterity following initial treatment such as chemotherapy, radiation therapy or hormone therapy. The women were part of the Life After Cancer Epidemiology cohort, and were followed for up to 11 years after diagnosis.

Outcomes differed according to disease stage. Women with localized cancer had higher rates of non-breast cancer death due to functional limitations than those with more advanced disease. In addition, women with functional limitations may have poorer treatment tolerance because they are more likely to be older, less physically active, and overweight or obese. As a result, the authors speculate that women with good physical function who tolerated therapy well might be over-represented in the group with more advanced disease.

"There is increasing evidence that regular physical activity, as little as 30 minutes of moderate intensity walking each day, can reduce the risk of breast cancer recurrence,'' said study co-author Patricia Ganz, MD, a medical oncologist and director of cancer prevention and control at UCLA's Jonsson Comprehensive Cancer Center. "Women with functional limitations are less likely to be able to maintain regular physical activity and would likely benefit from intervention to reduce their limitations and increase physical activity.''

Though the researchers did not specifically study the mechanism, they suggest that functional limitations may be associated with chronic inflammation, a key aspect of the immune system's defenses, which can lead to diminished function of organs or systems.

In an accompanying editorial, Harvey Jay Cohen, MD, director of the Center for the Study of Aging and Human Development at Duke University Medical Center said the research "enhances our broader understanding of the issues surrounding functional status assessment and cancer outcomes.'' jnci.oxfordjournals/content/early/2010/09/22/jnci.djq365.full.pdf+html.

Source: University of California -- San Francisco