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Importance of cell-cell communication in ischaemia

March 14, 2017

Inhibiting Dll4, so that the Notch receptor was no longer activated, caused the formation of a disorganised, low-perfused blood vessel network in the ischaemia heart and muscle, and eventually muscle degeneration. Another problem that occurred after inhibiting Dll4 was that there was an enhanced inflammatory response to ischaemia ??“ the muscles became infiltrated with leukocytes (a type of white blood cell) because of the activation of a specific cytokine mechanism.

Professor Paolo Madeddu said: ???Our findings reveal a novel mechanism that co-ordinates new blood vessels and inflammation in ischemia to ensure proper healing. But future studies are needed to verify whether dysregulation of this mechanism contributes to inefficient angiogenesis and prolongation of inflammation in ischemic disease.???

These results demonstrate that the Dll4-Notch interaction is fundamental for the formation of a functional vascular network in ischaemic tissues. Moreover, Dll4/Notch signalling plays an important role in coordinating inflammation and angiogenesis to the aim of ensuring proper tissue healing.

Paper: Inhibition of Delta-Like-4??“Mediated Signaling Impairs Reparative Angiogenesis After Ischemia, Ayman Al Haj Zen, Atsuhiko Oikawa, Miriam Bazan-Peregrino, Marco Meloni, Costanza Emanueli, Paolo Madeddu, Circulation Research, published online May 27, 2010.

Please contact Joanne Fryer for further information.

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