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DARA awarded $0.5M grant under Patient Protection and Affordable Care Act for advancing KRN5500 and DB959

October 26, 2017

The scientists caution that although their method gives them a more "real-life" model of the prostate with live tissue samples, it comes at a cost: - even with support, the tissues are short-lived, and experiments on fresh specimens must be completed within one week, which may be too short for some types of research.

The Hopkins-Helsinki team has already used their tissue-culture technique to measure levels of proteins known to repair DNA damage caused by carcinogens and other environmental agents. They found that one of these proteins - p53 - is not activated consistently enough to repair DNA damage. They also found that one of the first proteins to arrive on the DNA repair scene - H2AX - is activated at expected levels in all but one of the architectural compartments in prostate tissue. Low levels of H2AX were found in the so-called "luminal" compartment of prostate tissue, in the part of the prostate gland that produces secretions to protect sperm cells.

Laiho says the tissue-culture technique was a key component of understanding which DNA repair proteins may or may not be activated in different parts of prostate tissue and could help scientists develop therapies that target these DNA repair proteins.

The Hopkins and Helsinki investigators plan to use their new tissue-culture technique to test the response of experimental drugs on prostate cancer tissues.

Source: www.hopkinskimmelcancercenter